The fierce rivalry between the two sides deepened further, with the defeat marking back-to-back Championships for the Sixers and successive campaigns in which the team has trumped the Scorchers in the title decider.
The Scorchers won the toss and elected to bat, but a clinical display from the Sixers with the ball had Perth all out for 99, before the reigning champions chased down the total with nine wickets in hand and five overs to spare.
The Scorchers were put on the back foot early, as some tight and economical bowling from the Sixers had boundaries hard to come by and restricted the run rate to a little more than 3.5 an over through the powerplay.
The 0-22 was the Scorchers' lowest total through the period for the season, but ensured the side exited the first six overs without loss.
However, it was a benefit that was short lived, as skipper Elyse Villani (16 off 29) stepped down the pitch to take on Player of the Final Sarah Coyte (3-17(4)), missing the drive to be stumped.
Fellow opener Nicole Bolton (five off 12) fell the next over, trapped by right-armer Kim Garth (1-7(2)).
The Scorchers were 2-26, having lost two crucial wickets for just four runs following the powerplay and it was the run rate remaining below four an over that was posing challenges for the Perth batters.
The fast-striking Natalie Sciver (two off two) and Megan Banting (five off nine) were put together in an attempt to overcome the slow start, but the task became harder when the former was caught behind, edging Ellyse Perry (1-9(2)).
The Scorchers had lost 4-19 in 22 deliveries when Banting fell to a good catch at mid wicket off Erin Burns (2-26(4)), finding themselves in trouble at 4-41 in the 11th over.
Several batters attempted to make progress, but the wickets continued to fall.
A Lauren Ebsary (four off four) four in the 16th offered a glimmer of hope as the first boundary in 10 overs, but it was short lived as Coyte had the former international caught behind next ball and the Scorchers at 7-71.
A late flurry from bowler Piepa Cleary (18 not out from 14) had the Scorchers approaching triple-figures, but the run out of Emily Smith for a diamond duck as the pair scurried for two on the last ball instead had Perth end its innings on 99 all out.
The 100 for victory loomed as a nerve-racking total for the Sixers if not handled correctly, but openers Alyssa Healy (41 off 32) and Perry (36 not out from 42) made few errors.
The Scorchers had performed admirably to hold the run rate at bay for much of the powerplay, until Healy struck three fours off the fifth over to build a 0-39 launchpad.
The Sixers threatened to achieve the chase without loss, until the change to spin paid dividends, with Emma King (1-26(4)) beating the bat to have a charging Healy stumped.
Destructive batter Ashleigh Gardner (22 not out off 16) entered with her side 1-64 in the 11th, requiring just 36 runs from 57 balls for victory.
It was a total that proved too little for the Scorchers to defend and the power-hitting pair soon achieved the 100-to-win with an even five overs to spare.