The Scorchers won the toss and elected to bowl first against a confident Adelaide outfit.
The Strikers struggled to get going with the bat in the first 10 overs against the Scorchers, but Tahlia McGrath stepped up, smashing a team-high 34 off 28, including two fours.
Despite only posting a modest total of 107, the Strikers built the pressure early for the Scorchers' batters, restricting them to 2-23 after seven overs.
It became 3-29 after nine, 4-45 after 11 and 5-48 after 12, before a four and six on consecutive balls from Thamsyn Newton gave the Scorchers hope.
But wickets on the last two balls of the 14th over to Megan Schutt snuffed that hope out.
The Strikers brilliant fielding and bowling performance resulted in the Scorchers going all out for 76 runs in 17.3 overs, in their attempt to chase down 108 for victory.
For the players in orange, it was Katherine Brunt (2-15) and Heather Graham (2-23) who were the pick of the Scorchers' bowlers.
Nicole Bolton was the pick of the batters for the Scorchers, posting 30 off 38, including four fours.
The Perth Scorchers' next game is against the Hobart Hurricanes on Saturday January 20 at #TheFurnace, with the first ball to be bowled at 1.30pm WST.