After winning the toss and electing to bowl, the Scorchers burst out of the blocks and had the Thunder 3-22 through the first five overs.
Leg spinner Sarah Glenn opened the bowling and was again in fine form, taking 1-13 from her four overs.
However, a century partnership between Rachel Haynes (61*) and Heather Knight (57) steadied the innings and boosted the Thunder to 4-144 from their 20 overs.
Prized recruit Beth Mooney (61) fired with the blade at the top of the order and notched up her 300th four in WBBL cricket, becoming the first player to reach the milestone.
The opener combined with Nicole Bolton (19) to set a promising platform, but once Bolton was dismissed the wickets fell regularly, with the Scorchers eventually bowled out for 120.
Beth Mooney was optimistic of Perth’s immediate future when speaking post-match.
“We’ve got a pretty well-rounded bowling attack, we’re perhaps not executing exactly how we’d like, which is ok, that’s an easy fix,” she said.
“We’ve got a great group of players and great support staff… there’s no doubt we’ll be able to turn this around.
“I 100% back the group that we’ve got to win some games and gather some momentum.”
The Scorchers will now turn their attention to a Saturday night blockbuster against the Melbourne Stars at North Sydney Oval.