With the mercury sailing past 40 degrees at Albrecht Oval, The Scorchers couldn’t contain New Zealand all-rounder Sophie Devine, as she scored a pivotal 59 off 48 deliveries to underpin the Strikers' 7-138.
In reply the Scorchers were bowled out for 108.
Rising star Heather Graham (2-25) extended her lead as this season's leading WBBL wicket-taker while Kate Cross, despite not picking up a wicket, was arguably the pick of the attack.
The England seamer conceded just 13 runs from her four overs and strangled the Strikers during the powerplay and at the death to give Perth a fighting chance.
But the Scorchers found themselves in early trouble when in-form skipper Meg Lanning, who had posted four 70-plus scores in her previous five knocks, chipped Megan Schutt (2-21) to a diving Bates at cover in the opening over.
After starring with the bat, Devine then struck with her first ball, knocking over the dangerous Villani (13), who never quite looked right in her comeback from a hamstring strain.
The Scorchers looked gone at 5-59 when Graham departed cheaply before Lauren Ebsary threatened to produce a late twist.
The veteran hit a breezy 38 but she lacked any support and eventually holed out to Tabitha Saville off experienced English spinner Danielle Hazell (3-20).
The Melbourne Renegades’ three run win over Hobart this afternoon means the Scorchers are now out of finals contention, with their last match tomorrow against the Strikers back at Albrecht Oval.