After being sent into bat first at St Kilda's CitiPower Center, the Scorchers were in trouble early after captain Meg Lanning edged behind on two.
England internationals Amy Jones (44) and Nat Sciver (55*) steadied the ship for the visitors, combining for a 76 run second wicket partnership.
From there, the Scorchers couldn't generate any momentum with the bat, eventually posting 5-132 from their 20 overs.
Piepa Cleary made the early breakthrough with the ball for her side, removing the dangerous Sophie Molineux (24) in the sixth over.
Nicole Bolton put forward an early nomination for catch of the season, completing a stunning caught and bowled to remove the Renegades England international Tammy Beaumont (25.)
First gamers Jemma Barsby and Kim Garth enjoyed wickets in their debut match for the Scorchers, Barsby finished with figures of 2-22 while Garth claimed 1-21 from her four overs.
Several missed chances in the field proved costly for the Scorchers, with the home side chasing down the total with five balls to spare.
The Scorchers will fly to Brisbane tomorrow ahead of the Queensland Big Weekend, where they'll play the Brisbane Heat on Saturday before taking on the Adelaide Strikers on Sunday.