Captain Adam Voges won the toss and sent England into bat, forcing the visitors to be the first to make runs on the new drop-in wicket.
Batter Liam Livingstone led the scoring for the Lions with 36 to help his side reach 6-160.
Scorchers all-rounder David Willey disregarded friendship with his countrymen to make a welcome return to orange, collecting best bowling figures of 3-32.
Joel Paris, Andrew Tye and James Muirhead, who is uncontracted and training with the squad, all managed a wicket each on the new surface.
Hilton Cartwright was the pick of the Scorchers batters and looked comfortable in the 60,000 seat stadium, finishing on 56 runs from 41 deliveries, including two fours and three sixes.
For the visitors, Lions fast bowler Sajid Mahmood proved damaging, claiming 4-14 off four overs.
“It was a good hit out for the guys, obviously you still want to win every game but we understand that this is a good lead-up to the Big Bash against some good opposition,” Voges said.
“Hilton Cartwright batted really nicely, took a little while to get himself settled but he did really well.
“It was great to have David Willey back and see him in amongst the wickets.
“All in all, there are some really good things to take out of the game, but there are definitely improvements to be made.”
The Scorchers play the England Lions again on Wednesday 13 December at Optus Stadium.