English all-rounder Nat Sciver smacked 52 off 37 balls to help the Scorchers post 5-152 from their 20 overs.
The 27-year-old hit seven boundaries before holing out in the last over. Lanning (28) was stoic at the top before Heather Graham (25 not out) produced a late flurry.
Perth's bowlers then restricted the Sixers to 9-100 in reply, led by Kim Garth (2-15) and Heather Graham (2-17) with Sciver taking 1-27 from her four overs to round out her Player of the Match performance.
After losing Alyssa Healy (2) to a superbly judged catch from Scorchers skipper Meg Lanning off the fourth ball of the second innings, the Sixers were never in the hunt as they slumped to their third successive defeat.
Clearly feeling the absence of superstar captain Ellyse Perry (shoulder injury), the Sixers crashed to 5-35 in the ninth over.
The landslide victory allowed the Scorchers to leapfrog the Sixers into third position on the ladder.
Fans were treated to a show on and off the field, with a carnival style set up at the community ground entertaining the crowd of 1224 and a record breaking dog attendance of 20 furry friends.
The Scorchers and the Sixers go back-to-back, facing off again tomorrow (Sunday 24 November) at Lilac Hill at 10am WST.