Elyse Villani played a composed captain's knock at the top of the order, posting 45 off 55 balls, but she received little support with no other batter getting a start.
Brisbane's bowlers piled on the Heat from the outset, which put the Scorchers batters under pressure.
Chloe Piparo and Lauren Ebsary managed to stay out in the middle with Villani long enough to help get their teams total into triple figures.
The home sides batters got to work early, chasing down the target of 103 with seven overs to spare.
Head Coach Lisa Keightley said her side couldn't gather any momentum during their batting innings.
"Brisbane bowled really well in the power play early on, they didn't allow our batters to get on top in the beginning of our innings," Keightley said.
"We were under pressure early and we were too sluggish with the bat, we just weren't quite on today.
"It was tough to bounce back from last night's match, tough for the girls to back up, but in the end we just didn't score enough runs today to give ourselves a chance.
"I am proud of the way the girls fought hard to drag out the contest for as long as we could."
The Scorchers travel back to Perth tomorrow, ahead of their next set of matches against the Stars in Melbourne and the Hurricanes in Hobart.